of simple cells (prokaryotes). - About 3.5 - 3.8 billion years, of land plants. - 475 million years, of insects and seeds. - 400 million years, of amphibians. - 360 million years, of reptiles. - 300 million years, of mammals. - 200 million years, of birds. - 150 million years, of flowers. - 130 million years , since the non-avian dinosaurs died out. - 65 million years, since the appearance of Homo. - 2.5 million years, since the appearance of modern humans. - 200,000 years, since Neanderthals died out. - 25,000 years,

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