1st Generation - Typical: Chlorpromazine, Loxapine, Fluphenazine, Perphenazine, Thioridazine, Pimozide, Haloperidol, Lowers seizure threshold, Treats positive s/sx only, Causes more sedation, Look for parkinsonism, Haloperidol and Fluphenazine - available as a depot shot, 2nd Generation- Atypical: Clozapine - risk for agranulocytosis, Olanzapine - most weight gain, Quetiapine - most sedation, Risperidone - most dyskinesia, Ziprasidone - most QT prolong, Aripiprazole - causes uncontrollable urges, Asenapine - sublingual and patch available, Risk for malignant metabolic syndrome, Treats negative and positive s/sx, Costs more,

Antipsychotics - 1st vs 2nd generation

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